Howard Dintzis and Renee Dintzis were both longtime faculty members in the Johns Hopkins School of Medicine Department of Biophysics and Biophysical Chemistry. The husband and wife scientists first met in graduate school at Harvard. Prior to coming to Hopkins, their work brought them to Yale University, Cambridge University, the California Institute of Technology, and the Massachusetts Institute of Technology. In this oral history, Howard and Renee Dintzis discuss their life's work as scientists and some of their notable colleagues and students, including Francis Crick. Renee Dintzis also discusses balancing motherhood with her scientific career and the experience of being a woman in a male-dominated field. This oral history is part of the Hopkins Retrospective oral histories series.