Samuel Hopkins was a Baltimore businessman, and advocate for preservation of Maryland historic sites. Hopkins was born and raised in Howard County and graduated from Johns Hopkins University in 1934. He was the great grand nephew of Johns Hopkins. Hopkins was active in politics and philanthropy in Maryland, and served as president of the Maryland Historical Society from 1970 to 1976. In this oral history, Hopkins describes his family's history and impact on the city of Baltimore, describing Johns Hopkins career and relationships with contemporaries such as Enoch Pratt, Moses Sheppard, and George Peabody. Hopkins also discusses life on campus during his time as a student during the Great Depression, describing his relationships with prominent faculty members such as Dr. Frederic Chapin Lane and Dr. Broadus Mitchell, as well as student organizations and activities. This oral history is a part of the Mame Warren oral histories series.