Host Lynn Poole reviews highlights of programs from the past year: "Freezing the Atom" (10/10/50) shows how atoms are slowed down and the development of the bolometer; "Electronics at Work in a Vacuum"(10/25/50) describes the development of the vacuum tube and the principles behind it, using puffed wheat in a jar as an example; "Your Questions About Science" (12/26/50) explains and demonstrates atomic chain reaction or nuclear fission using mouse traps and sugar cubes; "The Unbreakable Laws of the Universe" (1/2/51) explains the physical laws governing all things: inertia, action and equal reaction, conservation of motion, gravity, and atmospheric pressure; "Fight Against Polio" (1/16/51) filmed at the Children's Hospital in Baltimore, MD, shows how polio victims are being strengthened and restored to a normal life; "Don't Take Your Heart for Granted" (2/13/51) describes what the heart is, what can happen to it, and how to take care of it; "Archaeology: Key to the Past" (3/13/51) looks at the work of archaeologists and their study of the lost civilization of the Etruscans; "Cancer Will Be Conquered" (4/10/51) features Dr. Gey describing the differences between normal and cancerous cells and showing a magnified, live view of the separation of normal and abnormal human cells; "Is There Science in Art?" (2/27/51) reveals the science of cleaning varnish and dirt from old paintings at the Walters Art Gallery and the art of using x-rays and ultraviolet light to restore old paintings to their original intent. Poole also thanks the studio staff and mentions other favorite programs: "Fear" (103/50), "X-Ray, the Super Sleuth" (12/5/50), "Stream Pollution" (5/1/51), "Don't Drink That Water" (3/20/51), "Schistosomiasis" (11/21/50), and "Magnificent Microscope" (5/15/51).

The program begins with a tour of the Children's Hospital School of Baltimore, Maryland. Dr. Raymond Lenhard describes the symptoms of poliomyelitis, or infantile paralysis, and treatment of the disease. In the exercise room, a physical therapist demonstrates the muscle test for fingers and shoulders and how patients progress from simple to complex exercises. Patients are shown in crutches and leg braces, in the rocking bed, and in the treatment pool doing underwater exercises. "Iron lung" respirators are demonstrated and explained. Lynn Poole interviews two patients who recovered from polio, and he alludes to research being done in polio immunization.